4:05 p.m. ET | FOX

Matchup rating: 47.3 | Spread: LAR -13 (47)

What to watch for: The Giants are really struggling amid an 0-3 start, scoring an average of only 12.3 points per game. The Rams offense, however, is finding its stride behind quarterback Jared Goff and is unlikely to slow down against a defense that’s allowing 26.3 points per game. Watch for the Rams’ running game to get moving behind Darrell Henderson Jr. and for Goff to establish early connections with a plethora of targets with Giants defensive back Jabrill Peppers unlikely to play because of an ankle injury. — Lindsey Thiry

Bold prediction: Aaron Donald produces double-digit QB pressures. He’s done it before (Week 1 against the Cowboys), so why not again against this Giants offensive line which allowed seven to Bud Dupree in Week 1 and seven to Khalil Mack in Week 2? Donald versus Nick Gates, who was moved to center this season, is a massive mismatch. — Jordan Raanan

Stat to know: The Giants have an NFL-worst 170 rushing yards this season, the fifth-least total though three games in franchise history. On the other side of the field, the Rams’ Henderson is coming off a career-high 114 rushing yards last week, and Los Angeles has six TDs on the ground this season (only the Patriots have more this season with seven).

Injuries: Giants | Rams

What to know for fantasy: Henderson is averaging 6.1 yards per carry over the past two weeks with a rushing score in both of those games. See Week 4 rankings.

Betting nugget: Three of the last four times New York has been a double-digit underdog, it won the game outright, dating back to its Super Bowl XLII win over New England. Read more.

Raanan’s pick: Rams 31, Giants 20

Thiry’s pick: Rams 35, Giants 14

FPI prediction: LAR, 84.8% (by an average of 14.2 points)

Matchup must-reads: Giants preach optimism, but they’re not close to being a good team … The Rams extended Ramsey, Kupp and Woods: Now what? … Projected 2021 NFL draft order: Giants, Jets take over as favorites for No. 1 pick … Rams decry costly pass interference call that led to Bills’ go-ahead TD



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