1 p.m. ET | FOX

Matchup rating: 74.9 | Spread: BUF -2 (48)

What to watch for: Bills quarterback Josh Allen leads the NFL in scramble yards since entering the league in 2018, but Rams defensive tackle Aaron Donald ranks second in the league in sacks since 2014. It’s unstoppable force meets immovable object, and something’s got to give. — Marcel Louis-Jacques

Bold prediction: Rams running back Darrell Henderson Jr. rushes for 100-plus yards. Yes, the Bills’ defense ranks third in the NFL in rushing defense, allowing an average of 75.5 rushing yards per game, but Henderson gained 121 all-purpose yards in a Week 2 win, and he says he wasn’t even 100% with a lingering hamstring injury. Watch for him to find another gear in a breakout performance. — Lindsey Thiry

Stat to know: Stefon Diggs has 239 receiving yards this season, tied for the most in the NFL. The most receiving yards through the first three games of a season in Bills history is 352, by Peerless Price in 2002.

Injuries: Rams | Bills

What to know for fantasy: Two of Allen’s top five fantasy games of his career have come this season, and he’s averaging 65% more points per pass attempt than he did last season. See Week 3 rankings.

Betting nugget: The Rams are 13-5 against the spread (ATS) since the start of last season (2-0 this season). Read more.

Thiry’s pick: Rams 28, Bills 26

Louis-Jacques’ pick: Bills 24, Rams 21

FPI prediction: BUF, 52.9% (by an average of 1.1 points)

Matchup must-reads: Sports psychologist Carrie Hastings has become essential resource for Rams players … Playmaking WRs led by Diggs have Bills’ passing attack flying high … Henderson Jr. emerges as ‘closer’ in Rams’ running back committee

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